Lowering low-density lipoprotein cholesterol (LDL-C) is a core strategy in the prevention and treatment of cardiovascular diseases. Earthworm fibrinolytic enzyme, a potent fibrinolytic enzyme, has been proven to show potential efficacy in reducing LDL-C and improving vascular health. "BOTH" Freeze Dryer effectively remove moisture, reducing enzyme degradation and inactivation, thus prolonging shelf life. Furthermore, in terms of bioavailability, freeze-drying helps preserve enzyme activity, improves solubility, and enhances absorption and utilization in the body. This significantly boosts its LDL-C-lowering effects.
Ⅰ．Application of Freeze-Drying Technology in Preparing Earthworm Fibrinolytic Enzyme Lyophilized Powder
Freeze-drying, also known as lyophilization, is a process that removes moisture from substances using freeze-dryer equipment to preserve their structure and functionality. The preparation of earthworm fibrinolytic enzyme lyophilized powder involves two main steps: freezing and vacuum drying. This process effectively removes moisture from the enzyme extract while preserving its biological activity and stability.
Ⅱ．Cultivation of High-Quality Strains
Selecting high-yield strains for enzyme production is critical to the success of the manufacturing process. Through screening and improvement, strains with high activity and productivity are cultivated to enhance the enzyme production capacity.
Ⅲ．Extraction and Purification
Advanced extraction technologies are employed to isolate earthworm fibrinolytic enzyme from the strains, followed by purification to remove impurities. Common methods include ultrasonic disruption, centrifugation, and column chromatography, yielding a high-purity enzyme extract.
Ⅳ．Freeze-Drying Process
Using "BOTH" Freeze Dryer equipment, the enzyme extract is processed into stable lyophilized powder. During the freeze-drying process, parameters such as temperature and vacuum levels are adjusted to ensure the enzyme’s activity and stability are maintained.
Ⅴ．Advantages of Freeze-Dryer Technology
"BOTH" freeze-dryer technology offers the following advantages in improving the stability and bioavailability of earthworm fibrinolytic enzyme lyophilized powder:
Ⅵ．Advanced Freezing Technology
The newly designed -50°C freezing technology rapidly freezes the enzyme extract, preventing crystal formation and temperature fluctuations that could compromise enzyme activity.
Ⅶ．Precise Drying Control
The "BOTH" freeze-dryer features a precise drying control system, allowing temperature (-50°C to +45°C) and vacuum adjustments (1–30 Pa) based on process requirements. This ensures the enzyme’s stability and activity during drying.
Ⅷ．Analysis of LDL-C Reduction Effects
Lyophilized earthworm fibrinolytic enzyme processed with freeze-dryer technology retains high biological activity. Clinical trials demonstrate that its LDL-C-lowering effect significantly surpasses that of conventionally processed enzymes. The key factors include:
1.Enhanced Solubility: The lyophilized powder dissolves quickly in water, releasing active components and improving absorption and utilization in the body.
2.Activity Preservation: The freeze-drying process minimizes enzyme inactivation, allowing it to act longer in the body and enhance LDL-C reduction efficacy.
The application of freeze-drying technology in preparing earthworm fibrinolytic enzyme lyophilized powder preserves enzyme activity and stability while improving bioavailability. This provides an effective drug formulation for lowering LDL-C and improving vascular health. With continuous advancements in freeze-drying technology, the widespread use of "BOTH" freeze-dryers in enzyme powder production offers new solutions for cardiovascular disease prevention and treatment.
If you are interested in our Freeze Dryer Machine or have any questions, please feel free to Contact us. As a professional manufacturer of freeze dryer machine, we offer a variety of specifications, including household, laboratory, pilot, and production models. Whether you need equipment for home use or larger-scale industrial equipment, we can provide you with the highest quality products and services.
Post time: Jan-13-2025
